ABSTRACT
Objective: To investigate the effect of thyroxine level on the onset of gestational diabetes mellitus (GDM), pregnancy outcome and the basic conditions of neonates. Methods: The related information of 1903 cases of pregnant women were prospectively collected from the Department of Obstetrics, Shanghai Changhai Hospital. Selecting group A (gravida with low thyroxinemia, n=36), group B (gravida with pure thyroid peroxidase antibody (TPOAb) positive, n=113) and group C (gravida with normal thyroid function, n=1539) according to the results of thyroid function test in newly constructed card. The incidence of GDM and the related index of thyroid function and glucose metabolism during the second trimester of pregnancy were compared among the three groups. Gravida with GDM in the three groups were group D (9 cases), group E (32 cases) and group F (367 cases), respectively. The differences of pregnancy outcome and the basic conditions of neonates among them were compared. Results: No significant differences existed (P>0.05) in the incidence of GDM during different pregnant period in groups A, B and C (First trimester: 50.00% vs. 25.00% vs. 34.69%; Second trimester: 21.88% vs. 28.71% vs. 22.70%). In the second trimester, the level of glycosylated hemoglobin (HbA1c) was significantly higher in group A than in group C [4.80%(4.60%, 5.00%) vs. 4.70%(4.40%, 4.90%)], w hi le the fasting glucose level was significantly higher in group B than those in group C [(4.69±0.59) mmol/L vs. (4.58±0.43) mmol/L, P0.05). Conclusions: Different levels of thyroxine have no significant effect on the incidence of GDM, but throw some effects on the glucose metabolism in the second trimester. In addition, positive TPOAb may increase the incidence of premature delivery and fetal distress in pregnant women with GDM, and affect fetal growth and development to some extent. Thyroid function status should be evaluated in the early stages of pregnancy, and regular follow-up should be conducted for patients with TPOAb positivity and timely intervention if necessary.
ABSTRACT
Objective To analyze the blood glucose levels and related data of inpatients of different clinical departments, so as to provide a basis for normalized management of blood glucose in hospital. Methods Medical records of 1 726 discharged patients from 9 different clinical departments of Changhai Hospital in November 2014 were retrospectively analyzed using medical record inquiry system. The data included admission blood glucose, metabolic indexes, hospital stay and hospitalization expenses. The abnormal blood glucose and related factors were analyzed. Results We found that 99.19% (1 712) of the 1 726 inpatients had their blood glucose monitored once at least. According to their past medical history and blood glucose levels on admission or during hospitalization, 42.76% (738) patients had pathoglycemia. Endocrinology department (73.79%,76/103), geriatrics department (54.17%, 13/24) and pancreatic surgical department (50.54%, 93/184) had more pathoglycemia patients than other departments. The patients with newly discovered pathoglycemia (393) accounted for 22.77% of the inpatients, and the hospital stay and hospitalization expenses in these patients were significantly higher than patients with diabetes and impaired glucose regulation (IGR) and those with normal blood glucose (P<0.01). The levels of serum triglyceride (TG) and blood urea (BUN) of diabetic and IGR inpatients were significantly higher than patients with newly discovered high glucose and normal glucose (P<0.01); the levels of high density lipoprotein cholesterol (HDL-C) in diabetic and IGR inpatients and those with newly discovered pathoglycemia were significantly lower than that in those with normal blood glucose (P<0.01), but there was no significant difference between the former two groups. Conclusion Newly discovered hyperglycemia during hospitalization should not be overlooked. The blood glucose monitoring of high risk population should be reinforced on admission and during hospitalization, and a standard management of hyperglycemia should be established.